The COVID-19 pandemic has led to uncertainty and anxiety, resulting in students’ high stress levels, which may influence their learning and academic self-efficacy. Considering stress and academic self-efficacy as significant variables in the academic context, the students’ levels of stress and academic self-efficacy amidst pandemic online learning were assessed to investigate the relationship between the aforementioned variables. Quantitative descriptive-correlational research was used in the study to collect, analyze, and interpret data gathered from 106 Human Ecology Students at the University of the Philippines Los Baños. The results indicated that students had severe stress levels and fairly often experienced stress during the COVID-19 pandemic. With regards to academic self-efficacy, students reported moderate level of academic self-efficacy during the pandemic. In the final analysis, the results of the current study led to a conclusion that there is a significant negative correlation between stress and academic self-efficacy, signifying that an increase in students’ stress levels leads to a decrease in their level of academic self-efficacy. Hence, this study highlights the importance of understanding stress and enhancing academic self efficacy of students, as these variables would be critical in promoting quality education and perhaps reducing students’ stress levels amidst pandemic online leaning.