The knowledge, attitudes, and practices (KAP) of students are fundamental to the growth of social enterprises (SEs) as the numbers continue to balloon. This study aimed to analyze the KAP toward SEs of UPLB BSHE and BSABME batch 2018 students. Specifically, the study identified the level of knowledge as well as the attitudes and practices on SE; compared the KAP on SE of the BSHE and BSABME students; and determined the factors affecting KAP among these students. Through analysis of KAP under the lens of human ecology, the findings of the study provided a glimpse into the potential of these socially-responsible businesses in playing a crucial role to resolve perturbations such as the COVID-19 pandemic. Students¶ KAP were analy]ed using descriptive and inferential statistics. Results showed BSHE and BSABME students have prior knowledge on social enterprises. Their attitude scores were also reflective of some favorable degree of agreement on social enterprise. Both groups were somewhat intentional in getting themselves involved with social enterprise. Moreover, BSHE students showed a stronger score on actual social enterprise practice than BSABME students. Finally, there was some degree of correlation between intervening variables such as age, sex and degree program on social enterprise knowledge, attitudes, behavioral intentions and practices. Awareness on social enterprise resulted in moderate level of knowledge and favorable outcomes for students. Hence, to better improve social enterprise KAP, policies at the university and national level must focus on the provision of support for social enterprise.