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The COVID-19 pandemic has caused closures of businesses and establishments due to the lockdowns and quarantine guidelines implemented by the government to limit the spread of the virus. In the Philippines, the concept of working from home was introduced to limit the movement of the people. This study aimed to assess the dietary intake, physical activity, and nutritional status of work-from-home mothers during the COVID-19 pandemic. Thus, these variables used descriptive analysis and Pearson correlation to evaluate the results. With this, changes in food consumption and physical activity were identified globally because of the restrictions caused by the COVID-19 pandemic and has been typically correlated to the nutritional status of individuals. From the results, the highest prevalence of obese I work from home mothers were identified with an average risk for CVDs in reference to the waist hip ratio (WHR) and waist circumference (WC). Variation in food intake, on the other hand, were seen regardless of the respondent’s nutritional status. However, specific food groups such as alcoholic beverage, ready-to-cook food, frozen food, chips and snack, and fast food were reported to be overconsumed across all body mass index (BMI) categories which may have affected the prevalence of overweight and obesity among the respondents. Moreover, 46% of the respondents were identified as inactive wherein 38% of which are overweight, obese I, and obese II. With this, the COVID-19 pandemic has played a role in the dietary behaviors and lifestyle activities of the respondents due to the stress and restrictions caused by the pandemic. Moreover, the unhealthy dietary patterns seen among the respondents may be accounted to the food availability and coping stress mechanisms caused by COVID-19.